The Association of Cytokine Genes Polymorphisms (IL1β+3954 C/T, IL18-137 G/C, and IL18-607 C/A) in Type 2 Diabetes Mellitus-tuberculosis
نویسندگان
چکیده
منابع مشابه
پلی‌مورفیسم ژن IL18 در بیماران دیابتی نوع I: یک مطالعه مورد- شاهدی
Background: Type I diabetes is an autoimmune disease characterized by T-cell Mediated destruction of pancreatic β-cells. A variety of environmental, genetic and Immunologic factors are involved in the development of the disease. IL18 is a cytokine secreted by macrophage and monocytes and play an important role in the pathogenesis of diabetes Type I through inducing IFN-γ production. It is shown...
متن کاملAssociation of IL18 gene polymorphisms (positions -656 G/T, -137 G/C and +105A/C) with Kala-Azar
Background & Objective: Host resistance to Leishmania infection is mediated by cellular immune responses leading to macrophage activation and parasite killing. IL-18 known as interferon-γ inducing factor, stimulate IFN-γ production by T-cells. According to the important role of IL-18 in defense against VL and known effect of IL-18 gene polymorphisms on its production, the aim of this study was ...
متن کاملIL18 production and IL18 promoter polymorphisms correlate with mortality in ICU patients.
BACKGROUND Single nucleotide polymorphisms in the promoter of interleukin (IL)-18 (-607C/A and -137G/C) may affect the clinical course of inflammatory diseases. This study examined the relationship between the plasma IL18 levels, IL18 promoter polymorphism, and outcomes in the intensive care unit (ICU) setting. PATIENTS AND METHODS Plasma IL18 levels, IL18 promoter genotype, clinical variable...
متن کاملAnalysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.
Recently, the interleukin-18 cytokine gene (IL18) was reported to be associated with type 1 diabetes. In the present report, we calculated that the reported genotypes of the two 5' region/promoter single nucleotide polymorphisms (SNPs), -607 (C-->A) (rs1946518) and -137 (G-->C) (rs187238), were not in Hardy-Weinberg equilibrium (HWE). We therefore investigated the association of the -607 and -1...
متن کاملThe association between serum lipids profile and HbA1c in type 2 diabetes mellitus in Tehran, Iran
Background and aims: Dyslipidemia is one of the major factors implicated in the development of the vascular complications of diabetes. In this study, it was evaluated the association between serum lipids profile and Hemoglobin A1c (HbA1c) in type 2 diabetes mellitus. Methods: In this cross-sectional study, the serum lipid profile and...
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ژورنال
عنوان ژورنال: Open Access Macedonian Journal of Medical Sciences
سال: 2020
ISSN: 1857-9655
DOI: 10.3889/oamjms.2020.5478